Effects of chronic immobilization stress on hippocampal brain-deprived neurotrophic factor and TrkB in juvenile and aged rats The WritePass Journal

Effects of chronic immobilization stress on hippocampal brain-deprived neurotrophic factor and TrkB in juvenile and aged rats Introduction Effects of chronic immobilization stress on hippocampal brain-deprived neurotrophic factor and TrkB in juvenile and aged rats IntroductionMethods AnimalExperimental ProcedureImmunohistochemistryQualitative AnalysisExpected ResultsDiscussionREFERENCESRelated Introduction The hippocampus is a vital region of the brain that regulates major aspects of learning, memory and emotions.   The hippocampus has also been linked in the regulation and control of anxiety response and conditioned fear (Yee et al. 2007) and yet it can also retain a high degree of plasticity (McEwen, Gianaros 2010). Looking at the structure of the hippocampus, one would find a curved arrow on either hemisphere. The curved region is known as the CA1-CA3 subfields which contain the pyramidal layer while the arrow known as the dentate gyrus (DG) is made up of a granular cell layer. The neurons in CA3 (the lower part of the curve) connects directly to CA1 (the upper part of the curve), which would receive input from the DG. Another component of the hippocampus is the brain-deprived neurotrophic factor (BDNF) and its specific receptor TrkB. It has been found that in previous research that there is a high level of BDNF expression in the central nervous system in which it plays an important role in the survival, protection, maintenance and differentiation from insults to neural cells (Barde, 1989). In the hippocampus however, BDNF helps with long-term potentiation (Figurov, 1996). The majority of the neural effects of BDNF are regulated by binding to the TrkB receptor (Barde, 1989). The BDNF and TrkB could also play a role in the stress response in hippampal neurons (Tapia-Arancibia et al. 2004, Pardon et al. 2005, Sirianni et al. 2010). Previous research has observed how BDNF and TrkB in the hippocampus play a role in the regulation of the HPA axis. Its role has to do with the termination of hypothalamopituitary-adrenocortical (HPA) axis responses to stress (Pizarro et al. 2004, McCormick et al. 2010), essentially the regulating the stress circuit to help maintain homeostasis (Herman et al. 1995). Other studies have found that this structure regulates the HPA axis through inhibiting its activity of BDNF and TrkB (Herman et al. 1996) and that hippocampal neurons can be hypersensitive to stress (Rot et al. 2009). They are especially vulnerable to long-term damaging influence of the glucocorticoids and can decrease expressions of BDNF (McEwen and Magarinos 2001, Bartolomucci et al. 2002, Murakami et al. 2005). It has been found that the consequences of long-term exposure to stress in the hippocampus can remodel hippocampal cells, which then can result in a malfunction of the affected area (Diamond et al.1996, Bremner 1 999). Different types of chronic or acute stress can modulate the reduction of BDNF and TrkB mRNA expression in the hypothalamus and in the pituitary gland of adult male rats (Rage 2002, Murakami 2005, Givalois 2001). Stress can play a more damaging role in the hippocampal regions of young and aged rats as well. Hippocampal vulnerability and reduction in neurotrophic factors have also been found in stressed and aging rats (Smith 1996, Li Yi 2009), and as well as in age-dependent rats that were postnatally exposed to maternal deprivation, which changed the BDNF expression in selected rat brain regions (Roceri, 2004).   All of which can possibly affect the structural synaptic plasticity which is has been found to be preserved in the dentate gyrus of aged rats (Geinisman, 1992) and has been linked to certain mood disorders (Duman, 2000). Many previous studies on the role of BDNF and TrkB in the hippocampus under certain stress conditions relied mainly on the observations of modifications in the matter of these proteins in adult animals during immobilization stress (Givalois et al. 2001, Rage et al. 2002, Marmigà ¨re et al. 2003, Reagan 2007). All of which has found a difference in the expression of BDNF in certain regions of the HPA axis in adult male rats, which again can lead to the dysfunction of that affected region. Furthermore, to my knowledge no reports have been published about chronic immobilization stress-induced responsiveness of BDNF and TrkB and their role in juvenile and aged animals exposed to immobilization stress during two critical stages of brain morphologic and functional transformations. The hypothesis of the proposed study is that juvenile rats will have a reduction of the hippocampal region than those of aged rats when exposed to chronic immobilization stress. Methods Animal Twenty male Sprague-Dawley rats from two age groups would be used for this study. The first group described as juvenile –JUV (postnatal 28 days) and the second group described as aged –AGE (postnatal 360 days).   They would be housed in groups of five animals per plastic cage in a room maintained under standardized light (8am to 8pm-hour light-dark cycle) and temperature (22 ±3 °C) conditions. They would be housed at least 1 week prior to the experiment. The animals would receive free access to food pellets and tap water. The care and treatment of the rats would be in accordance with the guidelines for laboratory animals established by the National Institute of Health as well as by the Local Ethical Committee of the University of Massachusetts Amherst. Experimental Procedure All tests were conducted once a day in 60-minute sessions for 20 consecutive days at the same time, between 10:00am and 3:00pm. JUV and ADT animals would be divided into experimental groups (n=5), exposed to chronic immobilization stress and control non-stressed groups (n=5), which would remain in their home cages until perfusion. The control animals would be handled for a few minutes daily by the same operator. The chronic stress stimulation would begin for JUV rats at postnatal seven days old. Chronic Immobilization Stress During each session, the animals would be immobilized in accordance with a well-established protocol (Badowska-Szalewska, 2010). Rats are fixed on a wooden board (18Ãâ€"25 cm) in a supine position by means of a leather belt, after which each of their legs was fixed at an angle of 45 ° to the body midline with adhesive tape (Badowska-Szalewska, 2010). Experimental and control animals were sacrificed on postnatal day 28 (JUV) and 360 (ADT), 90 min after the final session. All animals will be deeply anesthetized with a lethal dose of a drug (choice pending) and then perfuse with 0.9% saline solution with heparin, followed by 4% paraformaldehyde solution in 0.1 M phosphate buffer (pH 7.4) (Badowska-Szalewska, 2010). The brains will be removed and kept overnight and serial coronal sections of brain (40-ÃŽ ¼m-thick) will be cut. Immunohistochemistry   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Bordering sections would be processed for BDNF and TrkB with immunohistochemistry. The free-floating sections will be blocked in 10% Normal Goat Serum (NGS) for 2 hours and   incubated at 4 ºC for 3 days with the primary polyclonal rabbit anti-BDNF antibody and primary polyclonal rabbit anti-TrkB antibody (Badowska-Szalewska, 2010). After multiple rinses in a buffered saline (TBS), the sections will be incubated (2-3 hours, room temperature) with a secondary antibody. The controls for the immunohistochemical procedures will be processed with the same procedure with the exception of the primary or secondary antibodies. Therefore, no staining will be observed in the control slides. Qualitative Analysis An image analysis system will be used to analyze the number of BDNF-ir and TrkB-ir positive cells in the hippocampus. The total number will be divided into three (counted separately) areas of the hippocampus: CA1 subfield, CA3 subfield and dentate gyrus (DG). The cells that will be counted are the BDNF-ir cells or TrkB-ir cells in the pyramidal layer of CA1 and CA3, and in the granular layer of DG. The hemisphere and sampling will be chosen at random. The data will be analyzed by a two-way analysis of variance (ANOVA) for the factor groups (intact vs. chronic immobilization stress) and age groups (juvenile-JUV and aged-AGE). Expected Results Under chronic immobilization stress exposure, juvenile rats should have a significant decrease in the density of BDNF immunoreactive (ir) neurons and TrkB-ir cells should be observed in CA1, CA3 and DG. After chronic immobilization stress exposure of aged rats, the density of BDNF-ir and TrkB-ir cells should not decline in any of the sub-regions of the hippocampus. Discussion The present study would investigate the age-related changes in the density of BDNF-ir and TrkB-ir neurons in the under the exposure of immobilized stress. Prolonged forced swim has been found to affect the amount of BDNF-ir and TrkB-ir cells in the hippocampus of juvenile, not aged rats (Badowska 2010). The number of cells that contains these proteins would   be higher in DG than in CA1 or CA3, which is mostly to be related to the various   intrinsic and extrinsic interactions of the denrate gyrus (Amaral and Witter 1989). If proven, then the high levels of BDNF and TrkB that are present in the hippocampus indicate that these molecules have important physiological functions in different stages of life (Tapia-Arancibia et al. 2008). It is extremely important as demonstrated during adolescence; BDNF influences almost all aspects of development, including stimulation of growth, differentiation of neuronal stem cells and many other various roles (Mattson et al. 2004, Tapia-Arancibia et al. 2004). The flip side of the coin is that during aging, BDNF may play a protective role by preventing neurodegeneration, and stimulating sprouting in the hippocampus (Smith 1996, Tapia-Arancibia et al. 2004), or increasing neuronal repair (Smith et al. 1995). As for TrkB, it exerts positive influence on dendritic branching and dendrtic integrity/plasicity in the hippocampus (Sato et al. 2001), therefore a reduction in the level of this protein may be underlying factor in the synaptic changes that occur with age in the hippocampus (Geinisman et al. 1992). It is also known that adolescent rats, versus adult subjects, tend to be more susceptible to the influence of aversive stimuli, which is created by   HPA axis activation (Avital and Richter-Levin 2005, Lupien 2009), by the prolonged secretion of glucocorticoid (Romeo et al. 2004, Cruz et al. 2008, McCormick et al. 2010).   Also the expression of BDNF and TrkB is possibly regulated in opposite direction, meaning that the gr owth of BDNF content occurs with the fall in the level of TrkB in the hippocampal cells of aged rats (Frank et al. 1997, Nibuya et al. 1999, Sommerfeld et al. 2000, Silhol M et al. 2007, Tapia-Arancibia et al. 2008).Therefore, the higher density of BDNF-ir and the lower density of TrkB-ir cells in AGE group of experimental rats may signify their protective effects against hippocampal damage of aging animals in stress conditions. This study will demonstrate that hippocampal subfields of juvenile and aged rats show different density of BDNF and TrkB immunostaining cells. Chronic immobilization stress would influence the density of BDNF-ir and TrkB-ir in juvenile animals and the aged rats would be the determining factor in the changes in the density of BDNF-ir and TrkB-ir in the hippocampal regions. REFERENCES Alleva, E., Santucci, D. (2001). Psychosocial vs. â€Å"physical† stress situations in rodents and humans: role of neurotrophins. Physiol Behav 73: 313–320. Avital, A., Richter-Levin, G. (2005). Exposure to juvenile stress exacerbates the behavioural consequences of exposure to stress in the adult rat. Int J Neuropsychopharmacol 8:163173. Badowska-Szalewska, E., Klejbor, I., Cecot, T., Spodnik, JH., MoryÅ›, J. (2009). Changes in NGF/c-fos double staining in the structures of the limbic system in juvenile and aged rats exposed to forced swim test. Acta Neurobiol Exp (Wars) 69: 448–458. 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Signing this bill will allow the deliberate destruction of human embryos for the purpose of research which is damaging to our nation. In addition, it is widely acknowledged that the past president have used the veto power not merely to protect the constitution. The president has in the past used the veto power not merely as a means for protecting the constitution but also for various political purposes. It bears stressing that not all presidents have the support of the Congress. Several presidents in the past have to contend with a hostile Congress to get the needed legislations they wanted. If the president would not be firm in his response, it is possible that certain important pieces of legislations may not be passed at all. To avoid this from happening some presidents in the past have resorted to the extreme method of vetoing more laws to remind that that he holds the power. Consider the case of Franklin D. Roosevelt who in the past occasionally vetoed a piece of legislation simply to remind Congress that he is still in control (Richard E. Neustadt 1976) Harry Truman and Gerald Ford used the veto power for the purpose of determining differences in Congress to build a political base. (Neudstadt) It is the essence of democracy that the legislative and executive departments though they perform different tasks are co-equal. This may or may not be advantageous for the whole citizenry depending on the condition of the nation. It may happen that the country may experience economic difficulties. During this time, laws must be swiftly passed so that the needs of the people will be addressed more quickly. The ideal reaction would be that the Congress should communicate with the President so that they will have an understanding of what kind of laws need to be passed that can help improve the lives of the people. However, the exact opposite happens during economic difficulties. It is at this point that everybody wants to go grandstanding thinking that it is his best time to point the blame to another politician. It is at this time when every politician wants to be recognized for the littlest things he has done in the past. It is because of this reason that during economic difficulties and hardships there are more bills that are being vetoed by the president. Research has also shown that the president who feels that more voters are in his favor are more likely to use the veto power. The idea here is that the more the president thinks that he has the electorate on his side the more that he will tend to exercise this power to veto legislation. This could be measured by analyzing the results of the election in the past, the higher the votes the president gets the more likely it is that he will exercise this power. The political party who sponsored the bill may also influence the decision of the president whether he will veto it or not. The theory is that the more votes the bill receives from the members of his own party in Congress, the more likely that the president will sign the bill into law. On the other hand, the less votes the bill receives from the members of his own party, the more likely it is that the president will not sign the bill into law. Normally, when a bill is sponsored by a representative from a political party different from that o the president, the best thing for him to do if he seeks to have the bill passed into law is to compromise with the president and the other political party. Compromise can be manifested by deleting some portions of the bill which is objectionable on the part of the other political party. It bears stressing that if the sponsor of the bill refuses to eliminate these objectionable portions it is more likely that the president will likewise refuse to sing the bill into law and veto it. Conclusion The democratic system of government is indeed a complex system which requires the proper balance among its three branches. Based on the foregoing, there are many factors why a president may make use of his veto power. It could be because of the personality of the president. There are some presidents who are more inclined to veto legislations because they feel they have support of the electorate. President may also veto legislation because of the person sponsoring the bill. It is possible if the sponsor of the bill is someone other than a party mate of the president and the former does not make any compromises with the president such as deleting any objectionable portion of the bill then it is possible that the bill may be vetoed. Also, it could be because of the defects in the bill itself such as it is unconstitutional, unethical and immoral or may be because it is not yet timely.

Gender Roles in Society Essay -- Sociology Gender Sex Essays

Gender Roles in Society Suggested roles of all types set the stage for how human beings perceive their life should be. Gender roles are one of the most dangerous roles that society faces today. With all of the controversy applied to male vs. female dominance in households, and in the workplace, there seems to be an argument either way. In the essay, â€Å"Men as Success Objects†, the author Warren Farrell explains this threat of society as a whole. Farrell explains the difference of men and women growing up and how they believe their role in society to be. He justifies that it doesn’t just appear in marriage, but in the earliest stages of life. Similarly, in the essay â€Å"Roles of Sexes†, real life applications are explored in two different novels. The synthesis between these two essays proves how prevalent roles are in even the smallest part of a concept and how it is relatively an inevitable subject. Warren Farrell is a well educated man who focuses his attention on gender. In his essay â€Å"Men as Success Objects,† he writes about gender roles in male-female relationships. He begins, â€Å"for thousands of years, marriages were about economic security and survival† (Farrell 185). The key word in that statement is were. This implies the fact that marriage has changed in the last century. He relates the fact that post 1950s, marriage was more about what the male and female were getting out of the relationship rather than just the security of being married. Divorce rates grew and added to the tension of which gender held the supremacy and which role the individuals were supposed to accept. â€Å"Inequality in the workplace† covered up all of the conflicts involved with the â€Å"inequality in the homeplace†(Farrell). Farrell brings to attention all ... ...o accept. They help define male versus female. Most of the time these issues are taken lightly, and go unnoticed until someone or some group pays attention to the inequality and typical roles. It becomes interesting when roles are reversed in society to see how others react to those situations. Society seems to be getting more comfortable with female success, and less obsessed with women staying home to do housework. No matter how successful, there is always a struggle for dominance. It also seems to depend on how children are brought up as to how strongly those individuals strive to achieve their specific role. It will be interesting to see as society changes over time how the defined gender roles will continue to change as well. Whether it is the conflict of success, supremacy, or need for perfection roles will sustain time just as they have from the beginning.

Business Ethics Analysis

As permitted by Vietnamese law and labor regulations, Vietnamese subcontractors are permitted to employ hillier between the ages of 15 and 18 within their factories. This fact has infuriated children's rights activists in the united States (U. S. ) who feel that Nikkei is exploiting children in Vietnam to increase revenue. These activists protest the employment of children under the age of 18, and argue that children would have an opportunity to attend school and further their education if they are not forced to work.An opposing view of this argument is that children who accept employment within Vietnamese factories are doing so out of their own free will and feel fortunate o be earning an income to help contribute to the welfare of their family. Furthermore, secondary education in Vietnam Is not free as In the U. S. ; therefore, children who accept employment are most likely In a financial deficit and would likely not be able to afford to get a secondary education even If they had t he time to attend.Utilitarian model philosophy suggests that you should act in a way that generates the greatest benefit for the greatest number of people. Applying the utilitarian model to each of the prominent stakeholders from above gives a clear depiction of the pros and cons for both alternatives. A. Alternative #1: Continue to hire/employ underage workers For Alternative #1, in which Nikkei continues to hire and employ underage workers, there are more quantifiable positive outcomes than negative.Positive outcomes include increased income for Vietnamese workers and their families and reduced prices of Nikkei brand products, which is beneficial to both consumers and shareholders. There are several negative outcomes from continuing to employ children workers, which include Nikkei Corporation, Nine's CEO, and U. S. Global images remaining under scrutiny. Additionally, and most importantly, choosing to continue employing children in factories will likely to cause a consumer backlas h, reducing overall product sales.Alternative #1 : Continue to hire/employ underage workers Increased income for children's families Nine's public image suffers * Reduced prices for consumers U. S. Global image remains tarnished * Increased shareholder earnings* Reduced sales / consumer backlash *Increased revenue for Nikkei Increased scrutiny for CEO b. Alternative #2: Ban underage employment Applying the utilitarian model to Alternative #2, banning underage employment in Nine's factories, produces a negative quantifiable outcome. If Nikkei announced that it would no longer hire children, the corporation's public image, as well as the image of the U.S. N general, would improve, and Nikkei is likely to increase and expand its and increased consumer product costs) outweigh the positives for Alternative #2. Alternative #2: Ban underage employment Nine's public image improves * Increased poverty in Vietnam U. S. Global image improves * Costs of products increases Customer base expands Vietnamese children subjected to more harsh work environments Alternative favored: The Utilitarian Model, as displayed in the balance sheets above, favors Alternative #1, which is that Nikkei should continue to hire and employ underage workers. . Golden Rule Model The Golden Rule Model reflects the alternative that each of the key stakeholders would choose if given the choice: Key Stakeholder Alternative #1 Alternative #2 Employed/eligible Vietnamese children Yes No Families of employed/eligible Vietnamese children Yes Nikkei Corporation Yes No Other outsourced companies Yes No Consumers Yes No Nikkei CEO yes NO No Alternative favored: Alternative #1 is the clear choice for all of the key stakeholders using the Golden Rule Model. 3. Kantian Model a.Children in Vietnam are often depended upon in their society to go to work and ran an income in order to provide food and shelter for themselves and their families; therefore, they would argue for their right to do so by choosing Alternat ive b. Nikkei Corporation and other multinational companies are entitled to run their in which they operate. Nikkei would prefer Alternative #1 . C. Children's rights activists would argue that these child workers have the right to education, and that are prevented from doing so by being â€Å"forced† to work.These advocates for the Vietnamese children would be in favor of Alternative #2, banning all child labor in Nikkei factories. Alternative favored: The Kantian Model illustrates three significant societal values or rights that would be affected, with the majority in favor of Alternative #1 . 4. Enlightened Self-Interest Model Nikkei Corporation would view Alternative #1 , continuing to employ children in their overseas factories, as the most economically beneficial option.This alternative will reduce prices for consumers, increase shareholder earnings, and increase revenue for Nikkei. These benefits exceed the risks associated with Alternative #1, which mostly involves ta rnished images of Nikkei and its CEO. Alternative favored: Since the benefits to the decision maker (Nikkei) outweigh the harm caused to all other stakeholders, the Enlightened Self-Interest Model favors Alternative #1 .Moral Models – Best Fit The Utilitarian and Golden Rule Models are the most effective in determining which alternative is the best choice: Utilitarian Model: Alternative #1 has three (3) quantifiable pros vs.. Only one (1) con, whereas Alternative #2 zero (O) quantifiable pros as opposed to one (1) con. Golden Rule Model: All six (6) of the key stakeholders in this decision would benefit from Alternative #1 .Moral Models – Not a Good Fit Whereas the Utilitarian & Golden Rule Models clearly demonstrate that Alternative #1 is the best choice for all key stakeholders, the Kantian and Enlightened Self-Interest Models are not as convincing because they reflect the views of only a small portion of all stakeholders: Kantian Model: Alternative #1 positively aff ects two (2) out of three (3) social values or rights, whereas Alternative #2 only positively affects one (1). Comparisons within such a small sample size are not as convincing as the Utilitarian and Golden Rule Models.Enlightened Self-Interest Model: Although the most prominent stakeholder, Nikkei, would be positively affected by Alternative #1 , and said benefit outweighs any harm caused to all other stakeholders by choosing this alternative, the model advocates for the benefit of a single entity. The Utilitarian and Golden Rule Models take into consider a larger portion of all stakeholders who would be affected by this decision. Nikkei has been employing children in overseas factories for decades, during which time it has enduring many years of ridicule and criticism for doing so.Nikkei should try to improve its image to the public by taking the initiative to educate opponents of child labor with regard to the cultural differences between third-world countries and the U. S. They should specifically address the issue that it is not only the norm for children in those locations to work, but also that it is often a crucial for their survival. Additionally, Nikkei should enlighten critics about the educational norms of these children, emphasizing that most children over the age of 1 5 are not able to attend school because it is extremely costly and not enforced.

Defining Beauty Essay

The word â€Å"beauty† can mean an unlimited amount of things to so many people. Some people see beauty as a woman with a small figure, with her hair and makeup done like that of a model in a magazine. Others may see beauty as more of an internal asset, such as a woman giving more to this world than she knows she’ll ever get back. Still, many others may see beauty as something that is unattainable because the definition of it is so ironically undefined and ambiguous, that it may even be seen as non-existent. Beauty is extremely versatile and its definition is often debated because beauty has unlimited definitions. No one’s definition of beauty is wrong. However, it does exist and can be seen with the eyes and felt with the heart. The first and most commonly referred to definition of beauty is external beauty, or superficial beauty. â€Å"Beauty is only skin-deep†, as some people may say. The general public typically views beauty as something that often must be seen to be believed; a girl is not pretty unless she can prove it with appearance. â€Å"In the perpetual â€Å"body image debate† on Xanga and in the world, there are frequently posts that say, basically: â€Å"All sizes can be beautiful! It’s what’s inside that counts anyways!† Multiple commenters will agree with them, and everyone descends into gooey e-group-hugs. What they’re trying to do†¦ is nice. I won’t argue with â€Å"all sizes can be beautiful†Ã¢â‚¬â€œ I have my preferences and you have yours, and ideally we won’t bash one group or the other despite those preferences. I also won’t argue with â€Å"what’s inside counts,† because it’s obvious that one’s personality directly affects the way one is able to bond with people over time. But, to those who try to proclaim â€Å"looks don’t matter,† I say: Bullshit.† (Walker 2010). Whether this mentality is seen as ethically wrong or not, it IS a mentality and it IS acknowledged. If a person believes beauty is solely defined by physical appearance, then that is their individual opinion, and cannot be taken away from them, or marked as â€Å"wrong†. The second form of beauty, most naturally comes to mind as what’s known as â€Å"internal beauty†. You’ll most often hear things like â€Å"It’s what on the  inside that matters!† â€Å"Happy girls are the prettiest!† and the infamous â€Å"You have a great personality and that’s what matters!† Internal beauty IS what’s on the inside, obviously. Internal beauty is personality, charisma, lovingness, generosity; all the characteristics that typically make a person â€Å"beautiful† on the inside. â€Å"As I grew up, I began to realize outer beauty was not so important to make someone good. I remember a friend of mine who was so beautiful that every classmate wanted to talk with her, but she was very arrogant. She believed that she could do everything she wanted because she was so beautiful, but she lost friends one by one. My poor friend! But she learned a good lesson: inner beauty is more important than outer beau ty. After she learned that, she changed her attitude and made friends again.† (Ji 2010). Many people still believe that inner beauty is as important as outer beauty, while still some believe it is more important. This mentality is not wrong because it makes sense to the people that believe it. It must be acknowledged whether people think personality is more important than makeup, or not. And still, some people believe and feel that beauty can only be defined by the person who feels it. In other words, my internal and external beauty is examined and defined by the rest of the world, without me having anything to say about it. This particular definition says that that individual person, in this example being me; that I get to say whether I’m beautiful or not based off of how I feel, not the rest of the world, based off of one or both of the previous definitions. It is simply, what you define yourself as. â€Å"I know I looked beautiful that morning. Perhaps not to the young man holding his toddler in his arms who rode the elevator with me; perhaps not to the friend I met for lunch, a true believer in Botox; perhaps not to passersby on the street; but I knew it for a certainty. I was beautiful. I don’t believe that inner beauty is sufficient in this cruel world. That’s the pap one tells a child. I don’t believe that positive thinking improves your skin tone or that loving or being loved changes the shape of your nose or restores the thickness and color of hair, but I do know that there is a way of being beautiful, even as age takes its toll, that has something to do with the spirit filling with joy, something to do with the union with another human being, with the sense of having done well at something  enormously important, like making happy a man who has made you happy often enough.† (Roiphe 2012). Beauty cannot be defined as a single thing. It has no bounds; no limits as to say how beautiful something or someone can be, or if it’s beautiful or not. Beauty can’t be erased because it is forever living. No person sees it the exact same way. No one’s definition of it is incorrect because it has many definitions. Beauty exists, and can be felt more and more ways every day of our lives. Works Cited Ji, EunSuk. â€Å"Inner Beauty Is the Real Beauty – TOPICS Online Magazine | ESl/EFL | Sandy and Thomas Peters.† Inner Beauty Is the Real Beauty – TOPICS Online Magazine | ESl/EFL | Sandy and Thomas Peters. N.p., 07 Dec. 2010. Web. 13 Nov. 2013. . Roiphe, Anne. â€Å"What Makes Me Feel Beautiful.† Real Simple. N.p., 13 Aug. 2012. Web. 13 Nov. 2013. . Walker, Alexia. â€Å"Outer Beauty Totally Matters (Don’t Try to Deny It).† lovelyish.com. N.p., n.d. Web. 13 Nov 2013. .

Quotes About What a 50th Birthday Means

Quotes About What a 50th Birthday Means If you are turning fifty, my hearty congratulations on the golden jubilee celebrations! Let the wine pour and the music roll, as you watch your life unfurl. Now that you are free of several responsibilities, you can sit back and enjoy the fruits of your labor. Here are some wonderful 50th birthday quotes to keep you rocking for the next decade! Victor Hugo: Forty is the old age of youth; fifty is the youth of old age.TS Eliot: The years between fifty and seventy are the hardest. You are always being asked to do things, and yet you are not decrepit enough to turn them down.Sophie Tucker: From birth to age eighteen, a girl needs good parents. From eighteen to thirty-five, she needs good looks. From thirty-five to fifty-five, she needs a good personality. From fifty-five on she needs good cash.Coco Chanel: Nature gives you the face you have at twenty, but its up to you to merit the face you have at fifty.Elizabeth Cady Stanton: The heyday of womans life is the shady side of fifty!Bob Geldof: I do think I feel it but you dont think you are cause at a certain time you are no age but you dont think you are anything. You feel the life you have lived. I feel that. Its been a long fifty years.Dawn Wells: Just because a woman is over fifty does not mean she no longer has anything to offer. If anything, we have so much more to offer! We have lived life, we get better with age. I do my best work now in my 60s. Sure, I could retire; but what would I do? Play Bingo? I think not! Cindy Crawford: The face you have at age twenty-five is the face God gave you, but the face you have after fifty is the face you earned.

Alfred Nobel and the History of Dynamite

Alfred Nobel and the History of Dynamite The Nobel prizes  were established by none other than inventor Alfred Nobel. But besides being the namesake behind  one of the most prestigious awards given annually for academic, cultural and scientific achievements, Nobel is also well-known for making it possible for people to blow things up.  Ã‚  Ã‚  Ã‚   Before all that, however, the Swedish  industrialist, engineer, and inventor  built bridges and buildings in his nations capital Stockholm. It was his construction work that inspired Nobel to research new methods of blasting rock. So in 1860, the Nobel first started experimenting with an explosive chemical substance called  nitroglycerin. Nitroglycerin and Dynamite Nitroglycerin was first invented by Italian chemist Ascanio Sobrero in 1846. In its natural liquid state, nitroglycerin is very volatile. Nobel understood this and in 1866 discovered that mixing nitroglycerine with silica would turn the liquid into a malleable paste called dynamite. One advantage that dynamite had over nitroglycerin was that it could be cylinder-shaped for insertion into the drilling holes used for mining. In 1863, Nobel invented the Nobel patent detonator or blasting cap for detonating nitroglycerin. The  detonator used a strong shock rather than heat combustion to ignite the explosives. The Nobel Company built the first factory to manufacture nitroglycerin and dynamite. In 1867, Nobel received U.S. patent number 78,317 for his invention of dynamite. To be able to detonate the dynamite rods, Nobel also improved his detonator (blasting cap) so that it could be ignited by lighting a fuse.  In 1875, Nobel invented blasting gelatine, which was more stable and powerful than dynamite  and patented it in 1876. In 1887, he was granted a French patent for  ballistite, a smokeless  blasting powder  made from nitrocellulose and nitroglycerine. While Ballistite was developed as a substitute for black gunpowder, a variation is used today as a  solid fuel rocket propellant. Biography On October 21, 1833, Alfred Bernhard Nobel was born in Stockholm, Sweden. His family moved to St. Petersburg in Russia when he was nine years old. Nobel prided himself on the many countries he lived in during his lifetime and considered himself a world citizen. In 1864, Albert Nobel founded Nitroglycerin AB in Stockholm, Sweden. In 1865, he built the Alfred Nobel Co. Factory in Krà ¼mmel near Hamburg, Germany. In 1866, he established the United States Blasting Oil Company in the U.S. In 1870, he established the Socià ©tà © gà ©nà ©ral pour la fabrication de la dynamite in Paris, France. When he died in 1896, Nobel  stipulated the year before in his last will and testament that 94 percent of his total assets go toward the creation of an endowment fund to honor achievements in  physical science, chemistry, medical science or physiology, literary work and service toward peace.  Hence, the Nobel prize is awarded yearly to people whose work helps humanity. In total, Alfred Nobel held three hundred and fifty-five patents in the fields of electrochemistry, optics, biology, and physiology.

The effect of Spanglish on writers writing output Essay

The effect of Spanglish on writers writing output - Essay Example One major advantage of Spanglish is its ability to illustrate the power of the mind to play with words showing further inventive and creativity at some certain point. In other words, Spanglish could eventually make substantial touch in creative writing as in a way it could be highly viewed as creativity of the mind especially in aspects concerning words are played. In most of creative writing techniques, playing with words are normally highlighted just to help emphasize the main point of the writers and even emphasize their creative touch for more aesthetic feel. In other words, by this specific advantage, Spanglish eventually affects the way people right these days. People have creative ways and means to express themselves in writing and Spanglish eventually is a specific tool in helping them to wallow in deeper sense of creativity with words. Therefore, with Spanglish, there could be an assurance of achieving creative piece. There is eventually a market for Latino and Spanglish is remarkably accepted as an evolution of the language growth (Kevane & Heredia, 2000, p. 136). In other words, with Spanglish, it is not only on the point that creativity can be nourished, but with it also includes the fact that a writer would be able to use language freely and openly and allow it to grow or even execute the things it must necessary do. These are just some of the advantages of Spanglish, which substantially show that it has remarkable impact on the writer’s creativity to play with words in a positive way.... 240). In other words, Spanglish could eventually make substantial touch in creative writing as in a way it could be highly viewed as creativity of the mind especially in aspects concerning words are played. In most of creative writing techniques, playing with words are normally highlighted just to help emphasize the main point of the writers and even emphasize their creative touch for more aesthetic feel. In other words, by this specific advantage, Spanglish eventually affects the way people right these days. People have creative ways and means to express themselves in writing and Spanglish eventually is a specific tool in helping them to wallow in deeper sense of creativity with words. Therefore, with Spanglish there could be an assurance of achieving creative piece. There is eventually a market for Latino and Spanglish is remarkably accepted as an evolution on the language growth (Kevane & Heredia, 2000, p. 136). In other words, with Spanglish it is not only on the point that creat ivity can be nourished, but with it also includes the fact that a writer would be able to use language freely and openly and allow it to grow or even execute the things it must necessary do. These are just some of the advantages of Spanglish, which substantially show that it has remarkable impact on the writer’s creativity to play with words in a positive way. Disadvantages of Spanglish Spanglish is usually written by bilingual writers which means they also have to look out for readers who in nature are bilingual and have great affinity for combined languages (Castillo, 2005, p. 190). The problem therefore with Spanglish is finding for good markets for it. Hispanic are good market opportunities for Spanglish (Castillo, 2005, p. 190), but